KSHV LANA—The Master Regulator of KSHV Latency
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چکیده
منابع مشابه
KSHV LANA—The Master Regulator of KSHV Latency
Kaposi's sarcoma associated herpesvirus (KSHV), like other human herpes viruses, establishes a biphasic life cycle referred to as dormant or latent, and productive or lytic phases. The latent phase is characterized by the persistence of viral episomes in a highly ordered chromatin structure and with the expression of a limited number of viral genes. Latency Associated Nuclear Antigen (LANA) is ...
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Kaposi's Sarcoma-associated Herpesvirus (KSHV) establishes stable latent infection in B-lymphocytes and pleural effusion lymphomas (PELs). During latency, the viral genome persists as an epigenetically constrained episome with restricted gene expression programs. To identify epigenetic regulators of KSHV latency, we screened a focused small molecule library containing known inhibitors of epigen...
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Kaposi's sarcoma-associated herpesvirus (KSHV) is the etiological agent of Kaposi's sarcoma, primary effusion lymphoma (PEL), and multicentric Castleman's disease. Like other herpesviruses, KSHV establishes life-long latency in the human host with intermittent periods of reactivation. Physiological triggers of herpesviral reactivation are poorly defined. Toll-like receptors (TLRs) recognize pat...
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Kaposi's sarcoma(KS)-associated herpes virus (KSHV) or human herpesvirus 8 (HHV-8) is highly associated with KS, primary effusion lymphoma (PEL), and multicentric Castleman's disease, an aggressive lymphoproliferative disorder (1-3). Most tumor cells are latently infected with KSHV in which a small subset of viral genes are expressed (4-6). Of these latently expressed genes, the latency-associa...
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ژورنال
عنوان ژورنال: Viruses
سال: 2014
ISSN: 1999-4915
DOI: 10.3390/v6124961